Rhenish Hesse or Rhine Hesse is a region and a former government district in the German state of Rhineland-Palatinate. It is made up of territories west of the Upper Rhine river that were part of the Grand Duchy of Hesse and its successor in the Weimar Republic, the People's State of Hesse from 1816 to 1945. The hilly countryside is largely devoted to vineyards, comprising the Rheinhessen wine region.

Rhineland-Palatinate is a western state of Germany. It covers 19,846 km2 (7,663 sq mi) and has about 4.05 million residents. It is the ninth largest and sixth most populous of the sixteen states. Mainz is the capital and largest city. Other cities are Ludwigshafen am Rhein, Koblenz, Trier, Kaiserslautern, Worms and Neuwied. It is bordered by North Rhine-Westphalia, Saarland, Baden-Württemberg and Hesse and by France, Luxembourg and Belgium.