Rhodope is one of the regional units of Greece. It is part of the region of East Macedonia and Thrace. Its name is derived from the Rhodope Mountains, which cover the northern part of its territory. Together with the regional units Evros and Xanthi, it forms the geographical region of Western Thrace. The capital of the prefecture is the city of Komotini. The second largest town is Sapes. Most of the Muslims of Thrace, the only officially recognized minority in Greece, are settled in this area, where they form around half of the regional unit's population.

The Rhodopes are a mountain range in Southeastern Europe, and the largest by area in Bulgaria, with over 83% of its area in the southern part of the country and the remainder in Greece. Golyam Perelik is its highest peak at 2,191 meters (7,188 ft). The mountain range gives its name to the terrestrial ecoregion Rodope montane mixed forests that belongs in the temperate broadleaf and mixed forests biome and the Palearctic realm. The region is particularly notable for its karst areas with their deep river gorges, large caves and specific sculptured forms, such as the Trigrad Gorge.