Riverside Hotel was a hotel in Clarksdale, Mississippi, in operation since 1944. The fourth marker location on the Mississippi Blues Trail, famed for providing lodging for such blues artists as Sonny Boy Williamson II, Ike Turner, and Robert Nighthawk, it was previously the G.T. Thomas Hospital, in which Bessie Smith died in 1937.

Clarksdale is a city in and the county seat of Coahoma County, Mississippi, United States. It is located along the Sunflower River. Clarksdale is named after John Clark, a settler who founded the city in the mid-19th century when he established a timber mill and business. Clarksdale is in the Mississippi Delta region and is an agricultural and trading center. Many African-American musicians developed the blues here, and took this original American music with them to Chicago and other northern cities during the Great Migration.