Robert Hooke was an English polymath who was active as a physicist, astronomer, geologist, meteorologist and architect. He is credited as one of the first scientists to investigate living things at microscopic scale in 1665, using a compound microscope that he designed. Hooke was an impoverished scientific inquirer in young adulthood who went on to became one of the most important scientists of his time. After the Great Fire of London in 1666, Hooke attained wealth and esteem by performing more than half of the property line surveys and assisting with the city's rapid reconstruction. Often vilified by writers in the centuries after his death, his reputation was restored at the end of the twentieth century and he has been called "England's Leonardo [da Vinci]".

Sir Isaac Newton was an English polymath active as a mathematician, physicist, astronomer, alchemist, theologian, and author who was described in his time as a natural philosopher. He was a key figure in the Scientific Revolution and the Enlightenment that followed. His pioneering book Philosophiæ Naturalis Principia Mathematica, first published in 1687, consolidated many previous results and established classical mechanics. Newton also made seminal contributions to optics, and shares credit with German mathematician Gottfried Wilhelm Leibniz for developing infinitesimal calculus, though he developed calculus years before Leibniz.