The Archdiocese of Santa Fe is a Latin Church ecclesiastical territory or diocese of the southwestern region of the United States in the state of New Mexico. While the mother church, the Cathedral Basilica of St. Francis of Assisi, is in the city of Santa Fe, its administrative center is in the city of Albuquerque. The Diocese comprises the counties of Rio Arriba, Taos, Colfax, Union, Mora, Harding, Los Alamos, Sandoval, Santa Fe, San Miguel, Quay, Bernalillo, Valencia, Socorro, Torrance, Guadalupe, De Baca, Roosevelt, and Curry. The current archbishop is John Charles Wester, who was installed on June 4, 2015.

The Cathedral Basilica of Saint Francis of Assisi, commonly known as Saint Francis Cathedral, is a Roman Catholic cathedral in downtown Santa Fe, New Mexico. It is the mother church of the Archdiocese of Santa Fe.