The Archdiocese of Santo Domingo is a Latin Church ecclesiastical jurisdiction or archdiocese of the Catholic Church in the Dominican Republic. The see was erected 8 August 1511 as the Diocese of Santo Domingo and elevated to archdiocese on 12 February 1546.

The Cathedral of Santa María la Menor in the Colonial City of Santo Domingo is dedicated to St. Mary of the Incarnation. It is the first and oldest cathedral in the Americas, begun in 1504 and was completed in 1550. It is the cathedral of the Archbishop of Santo Domingo who has the honorary title of Primate of the Indies because this cathedral was the first diocese and the oldest cathedral established in the New World.