Rothschild loans to the Holy See refers to a series of major financial loans arranged between the Rothschild family and the Holy See of the Catholic Church. The first loan which occurred in 1832 took place in the aftermath of the Napoleonic Wars during the Pontificate of Pope Gregory XVI. This loan agreed on was for a sum of £400,000. A second loan occurred during the Pontificate of Pope Pius IX in the early 1850s with the same members of the Rothschild family after the collapse of Giuseppe Mazzini's short-lived revolutionary Roman Republic and the restoration of the Papal States.

The Rothschild family is a wealthy Ashkenazi Jewish noble banking family originally from Frankfurt that rose to prominence with Mayer Amschel Rothschild (1744–1812), a court factor to the German Landgraves of Hesse-Kassel in the Free City of Frankfurt, Holy Roman Empire, who established his banking business in the 1760s. Unlike most previous court factors, Rothschild managed to bequeath his wealth and established an international banking family through his five sons, who established businesses in London, Paris, Frankfurt, Vienna, and Naples. The family was elevated to noble rank in the Holy Roman Empire and the United Kingdom. The family's documented history starts in 16th century Frankfurt; its name is derived from the family house, Rothschild, built by Isaak Elchanan Bacharach in Frankfurt in 1567.