The Royal manuscripts are one of the "closed collections" of the British Library, consisting of some 2,000 manuscripts collected by the sovereigns of England in the "Old Royal Library" and given to the British Museum by George II in 1757. They are still catalogued with call numbers using the prefix "Royal" in the style "Royal MS 2. B. V". As a collection, the Royal manuscripts date back to Edward IV, though many earlier manuscripts were added to the collection before it was donated. Though the collection was therefore formed entirely after the invention of printing, luxury illuminated manuscripts continued to be commissioned by royalty in England as elsewhere until well into the 16th century. The collection was expanded under Henry VIII by confiscations in the Dissolution of the Monasteries and after the falls of Henry's ministers Cardinal Wolsey and Thomas Cromwell. Many older manuscripts were presented to monarchs as gifts; perhaps the most important manuscript in the collection, the Codex Alexandrinus, was presented to Charles I in recognition of the diplomatic efforts of his father James I to help the Eastern Orthodox churches under the rule of the Ottoman Empire. The date and means of entry into the collection can only be guessed at in many if not most cases. Now the collection is closed in the sense that no new items have been added to it since it was donated to the nation.

The Cotton or Cottonian library is a collection of manuscripts that came into the hands of the antiquarian and bibliophile Sir Robert Bruce Cotton MP (1571–1631). The collection of books and materials Sir Robert held was one of the three "foundation collections" of the British Museum in 1753. It is now one of the major collections of the Department of Manuscripts of the British Library. Cotton was of a Shropshire family who originated near Wem and were based in Alkington and employed by the Geneva Bible publisher, statesman and polymath Sir Rowland Hill in the mid 16th century.