Ségou Region is an administrative region in Mali, situated in the centre of the country with an area of 64,821 km2 (25,028 sq mi), around 5% of Mali. The region is bordered by Sikasso Region on the south, Tombouctou and Mopti on the east, Burkina Faso to the southeast and the Koulikoro Region to the west. In 2009 it had 2,336,255 inhabitants, making it the second most populous region of Mali. Its administrative capital is the town of Ségou.

Ségou is a town and an urban commune in south-central Mali that lies 235 kilometres (146 mi) northeast of Bamako on the right bank of the River Niger. The town is the capital of the Ségou Cercle and the Ségou Region. With 130,690 inhabitants in 2009, it is the fifth-largest town in Mali.