STS-47 was NASA's 50th Space Shuttle mission of the program, as well as the second mission of the Space Shuttle Endeavour. The mission mainly involved conducting experiments in life and material sciences inside Spacelab-J, a collaborative laboratory inside the shuttle's payload bay sponsored by NASA and the National Space Development Agency of Japan (NASDA). This mission carried Mamoru Mohri, the first Japanese astronaut aboard the shuttle, Mae Jemison, the first African-American woman to go to space, and the only married couple to fly together on the shuttle, Mark C. Lee and Jan Davis, contrary to NASA policy.

Space Shuttle Endeavour is a retired orbiter from NASA's Space Shuttle program and the fifth and final operational Shuttle built. It embarked on its first mission, STS-49, in May 1992 and its 25th and final mission, STS-134, in May 2011. STS-134 was expected to be the final mission of the Space Shuttle program, but with the authorization of STS-135 by the United States Congress, Atlantis became the last shuttle to fly.