STS-50 was a NASA Space Shuttle mission, the 12th mission of the Columbia orbiter. Columbia landed at Kennedy Space Center for the first time ever due to bad weather at Edwards Air Force Base caused by the remnants of Hurricane Darby.

Spacelab was a reusable laboratory developed by European Space Agency (ESA) and used on certain spaceflights flown by the Space Shuttle. The laboratory comprised multiple components, including a pressurized module, an unpressurized carrier, and other related hardware housed in the Shuttle's cargo bay. The components were arranged in various configurations to meet the needs of each spaceflight.