Sainte-Marguerite-Marie is a municipality in the Canadian province of Quebec, located in La Matapédia Regional Council Municipality. It was known as Sainte-Marguerite until October 30, 2010.

La Matapédia is a regional county municipality (RCM) in eastern Quebec, Canada at the base of the Gaspé peninsula, in the Bas-Saint-Laurent region. Its seat is in Amqui. It is named after the Matapédia River which runs through the western part of the RCM.