Samuel Griffin was a lawyer, soldier and politician from Virginia. Following his service during the American Revolutionary War as a Continental Army officer, Griffin served as mayor of Williamsburg, Virginia, as well as represented the former state capitol in the Virginia House of Delegates, then in the U.S. House of Representatives.

Cyrus Griffin, a Virginia lawyer and politician, was the final President of the Congress of the Confederation and first United States district judge of the United States District Court for the District of Virginia.