San Andres is a district of Manila, Philippines. San Andres shares the Estero Tripa de Gallina as its western and northern border with the districts of Malate and Paco, respectively and Pedro Gil and Tejeron streets to the east with the district of Santa Ana. It borders the cities of Pasay and Makati in the south. The area is under the jurisdiction of the Fifth Congressional District of Manila, and includes the Manila South Cemetery, an exclave of the city surrounded by land administered by Makati.

Manila, officially the City of Manila, is the capital and second-most-populous city of the Philippines. Located on the eastern shore of Manila Bay on the island of Luzon, it is classified as a highly urbanized city. As of 2019, it is the world's most densely populated city proper. It was the first chartered city in the country, and was designated as such by the Philippine Commission Act No. 183 on July 31, 1901. It became autonomous with the passage of Republic Act No. 409, "The Revised Charter of the City of Manila", on June 18, 1949. Manila is considered to be part of the world's original set of global cities because its commercial networks were the first to extend across the Pacific Ocean and connect Asia with the Spanish Americas through the galleon trade; when this was accomplished, it was the first time an uninterrupted chain of trade routes circling the planet had been established.