San Antonio, or unofficially San Ann or San An' as the locals call it, is a city in Pasco County, Florida, United States. It is a suburban city included in the Tampa-St. Petersburg-Clearwater, Florida Metropolitan Statistical Area, much more commonly known as the Tampa Bay Area. It lies within Florida's 12th congressional district. The population was 1,297 at the 2020 census.

Pasco County is located on the west central coast of the U.S. state of Florida. According to the 2020 census, the population was 561,691. Its county seat is Dade City, and its largest city is Zephyrhills. The county is named after Samuel Pasco.