The San Bernardino de Sena Estancia was a ranch outpost of Mission San Gabriel Arcángel in what is now Redlands, California, United States. It was built to graze cattle, and for Indian reductions of the Serrano people and Cahuilla people into Mission Indians. Over time, it fell into disrepair, until the early 20th century, when a new, larger structure was built as a museum. The new structure shares the same architectural style, but is not otherwise similar to the original buildings.

The Mexican Secularization Act of 1833, officially called the Decree for the Secularization of the Missions of California, was an act passed by the Congress of the Union of the First Mexican Republic which secularized the Californian missions. The act nationalized the missions, transferring their ownership from the Franciscan Order of the Catholic Church to the Mexican authorities.