The San Francisco Federal Building, formally the Speaker Nancy Pelosi Federal Building, is an 18-story, 234 ft-tall (71.3 m) building at 90 7th Street on the corner of Mission and 7th streets in the South of Market neighborhood of San Francisco, California. The federal building was designed by the Morphosis architectural firm, as a supplement to the Phillip Burton Federal Building several blocks away. Thom Mayne of Morphosis designed the building using a juxtaposition of gray concrete walls, perforated metal panels, and custom, faceted wood ceilings. The building was expected to be completed in 2005, but construction issues and delays pushed the project completion to 2007.

Morphosis Architects is an interdisciplinary architectural and design practice based in Los Angeles and New York City.