San Michele in Isola is a Roman Catholic church, located on the Isola di San Michele, a small islet sited between Venice and Murano, which once sheltered a Camaldolese monastery, but now houses the main cemetery of the city. The monastery was mostly demolished in the 19th century, but the church remains, originally rebuilt starting in 1469. The church is dedicated to Saint Michael, the holder of the scales on Judgement Day, a fit guardian of the sleep of the faithful dead. The island cemetery now includes the land of the formerly separate island of San Cristoforo. This church is sometimes referred to as San Michele di Murano, although this islet is separate from islands comprising that town.

Murano is a series of islands linked by bridges in the Venetian Lagoon, northern Italy. It lies about 1.5 km (1 mi) north of Venice and measures about 1.5 km (1 mi) across with a population of just over 5,000. It is famous for its glass making. It was once an independent comune, but is now a frazione of the comune of Venice.