Sanford station is a railroad terminal in Sanford, Florida. It is the southern terminus for Amtrak's Auto Train, which runs between this station and Lorton, Virginia. Amtrak reported in its fiscal years 2021 and 2022 reports that the station is Amtrak's busiest station in Florida. It reported station ridership of 269,381 according to the 2022 report.

Sanford is a city and the county seat of Seminole County, Florida. It is located in Central Florida and its population was 61,051 as of the 2020 census. It is part of the Orlando–Kissimmee–Sanford Metropolitan Statistical Area.