Santa Cruz de Tenerife, commonly abbreviated as Santa Cruz, is a city, the capital of the island of Tenerife, Province of Santa Cruz de Tenerife, and one of the capitals of the Canary Islands, along with Las Palmas. Santa Cruz has a population of 206,593 (2013) within its administrative limits. The urban zone of Santa Cruz extends beyond the city limits with a population of 507,306 and 538,000 within urban area. It is the second largest city in the Canary Islands and the main city on the island of Tenerife, with nearly half of the island's population living in or around it.

Tenerife is the largest and most populous island of the Canary Islands. It is home to 42.9% of the total population of the archipelago. With a land area of 2,034.38 square kilometres (785.48 sq mi) and a population of 948,815 inhabitants as of January 2023, it is also the most populous island of Spain and of Macaronesia.