Santa Maria sopra Minerva is one of the major churches of the Order of Preachers in Rome, Italy. The church's name derives from the fact that the first Christian church structure on the site was built directly over the ruins or foundations of a temple dedicated to the Egyptian goddess Isis, which had been erroneously ascribed to the Greco-Roman goddess Minerva.

The Temple of Isis and Serapis was a double temple in Rome dedicated to the Egyptian deities Isis and Serapis on the Campus Martius, directly to the east of the Saepta Julia. The temple to Isis, the Iseum Campense, stood across a plaza from the Serapeum dedicated to Serapis. The remains of the Temple of Serapis now lie under the church of Santo Stefano del Cacco, and the Temple of Isis lay north of it, just east of Santa Maria sopra Minerva. Both temples were made up of a combination of Egyptian and Hellenistic architectural styles. Much of the artwork decorating the temples used motifs evoking Egypt, and they contained several genuinely Egyptian objects, such as couples of obelisks in red or pink granite from Syene.