Santarcangelo di Romagna is a comune in the province of Rimini, in the Italian region of Emilia-Romagna, on the Via Emilia. As of 2009, it had a population of some 21,300. It is crossed by two rivers, the Uso and the Marecchia.

The province of Rimini is the southernmost province of the Emilia-Romagna region of Italy. Its capital is the city of Rimini, one of the "seven sisters" of the historical region of Romagna.