Santiago Rodríguez is a province in the northwest region of the Dominican Republic. It was split from Monte Cristi in 1948. The Santiago Rodríguez province has the Monte Cristi and Valverde provinces to the north, the Santiago province to the east, the San Juan and Elías Piña provinces to the south and the Dajabón province to the west.

The Dominican Republic is divided into thirty-one provincias, while the national capital, Santo Domingo, is contained within its own Distrito Nacional.