Sapohanikan was a Lenape settlement of the Canarsee now located in close proximity to where Gansevoort Street meets Washington Street near the Hudson River in Manhattan. The people of the settlement were violently displaced under Dutch Governor Wouter van Twiller in the 1630s, who operated a tobacco plantation for the Dutch West India Company.

The Meatpacking District is a neighborhood in the New York City borough of Manhattan that runs from West 14th Street south to Gansevoort Street, and from the Hudson River east to Hudson Street. The Meatpacking Business Improvement District along with signage in the area, extend these borders farther north to West 17th Street, east to Eighth Avenue, and south to Horatio Street.