Highway 1 is the Saskatchewan section of the Trans-Canada Highway mainland route. The total distance of the Trans-Canada Highway in Saskatchewan is 654 kilometres (406 mi). The highway traverses Saskatchewan from the western border with Alberta, from Highway 1, to the Manitoba border where it continues as PTH 1. The Trans-Canada Highway Act was passed on December 10, 1949. The Saskatchewan segment was completed August 21, 1957, and completely twinned on November 6, 2008. The speed limit along the majority of the route is 110 kilometres per hour (70 mph) with urban area thoroughfares slowing to a speed of 80–100 kilometres per hour (50–62 mph). Portions of the highway—the section through Swift Current, an 8-kilometre (5 mi) section east of Moose Jaw, and a 44-kilometre (27 mi) section between the West Regina Bypass and Balgonie—are controlled-access. Highway 1 serves as a major east–west transport route for commercial traffic. It is the main link between southern Saskatchewan's largest cities, and also serves as the province's main link to the neighbouring provinces of Alberta and Manitoba.

Indian Head is a town in southeast Saskatchewan, Canada, 69 kilometres (43 mi) east of Regina on the Trans-Canada Highway. It "had its beginnings in 1882 as the first settlers, mainly of Scottish origin, pushed into the area in advance of the railroad, most traveling by ox-cart from Brandon." "Indian" refers to Indigenous peoples in Canada. The town is known for its federally operated experimental farm and tree nursery, which has produced and distributed seedlings for shelter belts since 1901. For many years the program was run by the Prairie Farm Rehabilitation Administration (PFRA).