Highway 48 is a provincial highway in the Canadian province of Saskatchewan. It runs from Highway 1 at White City, about 10 kilometres (6.2 mi) east of Regina, to the Manitoba — Saskatchewan border, where it becomes Provincial Road 257. Highway 48 is about 238 kilometres (148 mi) long.

Highway 1 is the Saskatchewan section of the Trans-Canada Highway mainland route. The total distance of the Trans-Canada Highway in Saskatchewan is 654 kilometres (406 mi). The highway traverses Saskatchewan from the western border with Alberta, from Highway 1, to the Manitoba border where it continues as PTH 1. The Trans-Canada Highway Act was passed on December 10, 1949. The Saskatchewan segment was completed August 21, 1957, and completely twinned on November 6, 2008. The speed limit along the majority of the route is 110 kilometres per hour (70 mph) with urban area thoroughfares slowing to a speed of 80–100 kilometres per hour (50–62 mph). Portions of the highway—the section through Swift Current, an 8-kilometre (5 mi) section east of Moose Jaw, and a 44-kilometre (27 mi) section between the West Regina Bypass and Balgonie—are controlled-access. Highway 1 serves as a major east–west transport route for commercial traffic. It is the main link between southern Saskatchewan's largest cities, and also serves as the province's main link to the neighbouring provinces of Alberta and Manitoba.