The Catechetical School of Alexandria was a school of Christian theologians and bishops and deacons in Alexandria. The teachers and students of the school were influential in many of the early theological controversies of the Christian church. It was one of the two major centers of the study of biblical exegesis and theology during Late Antiquity, the other being the School of Antioch.

Exegesis is a critical explanation or interpretation of a text. The term is traditionally applied to the interpretation of Biblical works. In modern usage, exegesis can involve critical interpretations of virtually any text, including not just religious texts but also philosophy, literature, or virtually any other genre of writing. The phrase Biblical exegesis can be used to distinguish studies of the Bible from other critical textual explanations.