Second Presbyterian Church is a landmark Gothic Revival church located on South Michigan Avenue in Chicago, Illinois, United States. In the late nineteenth and early twentieth centuries, some of Chicago's most prominent families attended this church. It is renowned for its interior, completely redone in the Arts and Crafts style after a disastrous fire in 1900. The sanctuary is one of America's best examples of an unaltered Arts and Crafts church interior, fully embodying that movement's principles of simplicity, hand craftsmanship, and unity of design. It also boasts nine imposing Tiffany windows. The church was listed on the National Register of Historic Places in 1974 and later designated a Chicago Landmark on September 28, 1977. It was designated a National Historic Landmark in March 2013.

Michigan Avenue is a north-south street in Chicago that runs at 100 east on the Chicago grid. The northern end of the street is at Lake Shore Drive on the shore of Lake Michigan in the Gold Coast Historic District. The street's southern terminus is at Sibley Boulevard in the southern suburb of Dolton, but like many other Chicago streets, it exists in several disjointed segments.