The second gentleman or second lady of the United States is the informal title held by the spouse of the vice president of the United States, concurrent with the vice president's term of office. Coined in contrast to "first lady" – albeit used less commonly – the title "second lady" was apparently first used by Jennie Tuttle Hobart to refer to herself. The first second gentleman of the United States is Doug Emhoff, the husband of Kamala Harris, the current vice president and first female in the position, since January 20, 2021.

First Lady of the United States (FLOTUS) is the title held by the hostess of the White House, usually the wife of the president of the United States, concurrent with the president's term in office. Although the first lady's role has never been codified or officially defined, she figures prominently in the political and social life of the United States. Since the early 20th century, the first lady has been assisted by official staff, known as the Office of the First Lady and headquartered in the East Wing of the White House.