Second messenger system
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Second messengers are intracellular signaling molecules released by the target cell in response to exposure to extracellular signaling molecules—the first messengers. Second messengers trigger physiol
General Schematic of Second Messenger Mechanism
Inositol trisphosphate
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Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP3 or Ins3P or IP3 is an inositol phosphate signaling molecule. It is made by hydrolysis of phosphatidylinositol 4,5-bisphosphate,
Second messenger system
…They are one of the triggers of intracellular signal transduction cascades. Examples of second messenger molecules include cyclic AMP, cyclic GMP, inositol triphosphate, diacylglycerol, and calcium. First messengers are extracellular factors, often hormones or neurotransmitters, such as epinephrine, growth hormone, and…
PLC cleavage of PIP2 to IP3 and DAG initiates intracellular calcium release and PKC activation.