The Seney National Wildlife Refuge is a managed wetland in Schoolcraft County in the U.S. state of Michigan. It has an area of 95,212 acres (385 km2). It is bordered by M-28 and M-77. The nearest town of any size is Seney, Michigan. The refuge contains the Seney Wilderness Area and the Strangmoor Bog National Natural Landmark within its boundaries.

Schoolcraft County is a county located in the Upper Peninsula of the U.S. state of Michigan. As of the 2020 census, the population was 8,047, making it Michigan's fourth-least populous county. The county seat is Manistique, which lies along the northern shore of Lake Michigan. The county is named in honor of Henry Schoolcraft, who explored the area with the expedition of Lewis Cass. The county was founded in 1843 and organized in 1876. The county is largely rural and forested, with much of its western portion within Hiawatha National Forest.