Much of the territory of the modern state of Serbia was part of the Roman Empire and later the Eastern Roman Empire. In particular, the region of Central Serbia was under Roman rule for about 800 years, starting from the 1st century BC, interrupted by the arrival of the Slavs into the Balkans during the 6th century, but continued after fall of the First Bulgarian Empire in the early 11th century and permanently ended with the rise of the Second Bulgarian Empire in the late 12th century. The territories were administratively divided into the provinces of Moesia, Pannonia and Dardania. Moesia Superior roughly corresponds to modern Serbia proper; Pannonia Inferior included the eastern part of Serbia proper; Dardania included the western part of Serbia proper. After its reconquest from the Bulgarians by Emperor Basil II in 1018, it was reorganized into the Theme of Bulgaria.

Gamzigrad is an archaeological site, spa resort and UNESCO World Heritage Site of Serbia, located south of the Danube river, in the city of Zaječar. It is the location of the ancient Roman complex of palaces and temples Felix Romuliana, built by Emperor Galerius in Dacia Ripensis. The main area covers 10 acres (40,000 m2).