Serena Celia van der Woodsen Humphrey is a fictional character and the protagonist in the Gossip Girl novel series and in its TV adaptation, in which she is portrayed by Blake Lively. Serena is featured on the blog of the series' mysterious narrator, "Gossip Girl". Serena is known as the 'it girl of Manhattan' and is a character that appears to easily get whatever she wants because of her captivating beauty and charismatic personality. She is the daughter of a successful doctor, and a well known socialite/heiress.

Georgina Sparks is a fictional character in the Gossip Girl novel series and a recurring character on the television series of the same name, in which she is portrayed by Michelle Trachtenberg.