Sesame Workshop

Sesame Workshop the Children's Television Workshop, is an American nonprofit organization, responsible for the production of several educational children's programs—including its first and best-known, Sesame Street—that have been televised internationally. Television producer Joan Ganz Cooney and foundation executive Lloyd Morrisett developed the idea to form an organization to produce Sesame Street, a television series which would help children those from low-income families, prepare for school, they spent two years, from 1966 to 1968, researching and raising money for the new series. Cooney was named as the Workshop's first executive director, termed "one of the most important television developments of the decade". Sesame Street premiered as a series on National Educational Television in the United States on November 10, 1969, moved to NET's successor, the Public Broadcasting Service, in late 1970; the Workshop was formally incorporated in 1970. Gerald S. Lesser and Edward L. Palmer were hired to perform research for the series.

They hired a staff of producers and writers. After the initial success of Sesame Street, they began to plan for its continued survival, which included procuring additional sources of funding and creating other television series; the early 1980s were a challenging period for the Workshop. After Sesame Street's initial success, the CTW began to think about its survival beyond the development and first season of the show, since their funding sources were composed of organizations and institutions that tended to start projects, not sustain them. Government funding ended by 1981, so the CTW developed other activities, including unsuccessful ventures into adult programs, the publications of books and music, international co-productions, interactive media and new technologies, licensing arrangements, programs for preschools. By 2005, income from the CTW's international co-productions of the series was $96 million. By 2008, the Sesame Street Muppets accounted for $15–17 million per year in licensing and merchandising fees.

Cooney resigned as CEO in 1990. On June 5, 2000, the CTW changed its name to Sesame Workshop to better represent its activities beyond television, Gary Knell became CEO. H. Melvin Ming replaced Knell in 2011. In 2014, Ming was succeeded by Jeffrey D. Dunn. During the late 1960s, 97% of all American households owned a television set, preschool children watched an average of 27 hours of television per week. Early childhood educational research at the time had shown that when children were prepared to succeed in school, they earned better grades and learned more effectively. Children from low-income families, had fewer resources than children from higher-income families to prepare them for school. Research had shown that children from low-income, minority backgrounds tested "substantially lower" than middle-class children in school-related skills, that they continued to have educational deficits throughout school; the topic of developmental psychology had grown during this period, scientists were beginning to understand that changes of early childhood education could increase children's cognitive growth.

In the winter of 1966, Joan Ganz Cooney hosted what she called "a little dinner party" at her apartment near Gramercy Park. Attending were her husband Tim Cooney, her boss Lewis Freedman, Lloyd and Mary Morrisett, whom the Cooneys knew socially. Cooney was a producer of documentary films at New York public television station WNDT, won an Emmy for a documentary about poverty in America. Lloyd Morrisett was a vice-president at Carnegie Corporation, was responsible for funding educational research, but had been frustrated in his efforts because they were unable to reach the large numbers of children in need of early education and intervention. Cooney was committed to using television to change society, Morrisett was interested in using television to "reach greater numbers of needy kids"; the conversation during the party, which according to writer Michael Davis was the start of a five-decade long professional relationship between Cooney and Morrisett, turned to the possibilities of using television to educate young children.

A week Cooney and Freedman met with Morrisett at the office of Carnegie Corporation to discuss doing a feasibility study for creating an educational television program for preschoolers. Cooney was chosen to perform the study. In the summer of 1967, Cooney took a leave of absence from WNDT, funded by Carnegie Corporation, traveled the U. S. and Canada interviewing experts in child development and television. She reported her findings in a fifty-five-page document entitled "The Potential Uses of Television in Preschool Education"; the report described what the new series, which became Sesame Street, would be like and proposed the creation of a company that managed its production, which became known as the Children's Television Workshop. For the next two years and Morrisett researched and developed the new show, acquiring $8 million funding for Sesame Street, establishing the CTW. Due to her professional experience, Cooney always assumed the show's natural network would be PBS. Morrisett was amenable to broadcast it by commercial stations, but all three major networks rejected the idea.

Davis, considering Sesame Street's licensing income years termed

Governor Mifflin Senior High School

Governor Mifflin Senior High School is the only secondary school in the Governor Mifflin School District. It is located in Shillington, Berks County and serves students in the Reading area, it is named for prestigious Revolutionary War major and the first governor of Pennsylvania, Thomas Mifflin. Governor Mifflin Senior High School replaced Shillington High School in 1953; the Shillington High School building became the Governor Mifflin Junior High School. Governor Mifflin's mascot and logo is "Marvin the Mustang", the school competes at the AAAAA and AAAAAA level in the PIAA categories; as Shillington High School, it was notably attended by famed American author John Updike. Governor Mifflin Senior High School has a total enrollment of 1303 students; the school has a student teacher ratio of 15:1 including a graduation rate of 90%. The percent female population is 48% and male is 52%. John Updike- Famed Pennsylvanian author, notable for the novel "Rabbit, Run". Cheerleading Cross Country Field Hockey Football Golf Marching Band Soccer Tennis Volleyball Water Polo Basketball Bowling Cheerleading Rifle Swimming Wrestling Baseball Softball Lacrosse Softball Tennis Track and Field Volleyball The Governor Mifflin SGA is a student-run body that serves as the government of student affairs.

They serve to organize events such as Homecoming, Mini-thon, miscellaneous spirit events, Senior Awards. The Governor Mifflin TSA is a prestigious organization founded in 2016. TSA is an Organization that seeks to empower students by exposing them to events in the engineering sphere as well as other creative disciplines. Students compete in regional and can qualify for national competitions; the TSA is run by Tyler "The Robot" Smith. Mustang Mile and Key Club are Clubs run by serve in service roles in the school and state. Members of these organization seek to aid new students, participate in donation drive events and soup kitchens, assist in blood donations events through the Miller-Keystone Blood Center. Ping Pong Club has the largest membership of a club at Governor Mifflin High School after its creation in 2017 by Jakob Bolles, the current organizer. Students compete in three competitive brackets to decide, the ultimate Ping Pong champion. Fellowship of Christian Athletes Science Olympiad Enviorthon Its Our World Too French Club Spanish Club Thespian Society Anime Club Ski Club Mock Trial Gay-Straight Alliance Harry Potter Club Future Business Leaders of America Anime Club Governor Mifflin High School Governor Mifflin School District

Remogliflozin etabonate

Remogliflozin etabonate is a drug of the gliflozin class for the treatment of non-alcoholic steatohepatitis and type 2 diabetes. Remogliflozin was discovered by the Japanese company Kissei Pharmaceutical and is being developed by BHV Pharma, a wholly owned subsidiary of North Carolina USA-based Avolynt, Glenmark Pharmaceuticals through a collaboration with BHV. Remogliflozin was commercially launched first in India by Glenmark in May 2019. Remogliflozin etabonate was shown to enhance urinary glucose excretion in humans. Early studies in diabetics improved plasma glucose levels. Remogliflozin etabonate has been studied at doses up to 1000 mg. A pair of 12-week phase 2b randomized clinical trials of diabetics published in 2015, found reductions in glycated hemoglobin and that it was well tolerated. Remogliflozin etabonate is a pro-drug of remogliflozin. Remogliflozin inhibits the sodium-glucose transport proteins, which are responsible for glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine.

Remogliflozin is selective for SGLT2. Etabonate