The Shaftesbury Theatre is a West End theatre, located in Shaftesbury Avenue, in the London Borough of Camden. It opened in 1911 as the New Prince's Theatre, with a capacity of 2,500. The current capacity is 1,416. The title "Shaftesbury Theatre" belonged to another theatre lower down the avenue between 1888 and 1941. The Prince's adopted the name in 1963.

Shaftesbury Avenue is a major road in the West End of London, named after The 7th Earl of Shaftesbury. It runs north-easterly from Piccadilly Circus to New Oxford Street, crossing Charing Cross Road at Cambridge Circus. From Piccadilly Circus to Cambridge Circus, it is in the City of Westminster, and from Cambridge Circus to New Oxford Street, it is in the London Borough of Camden.