Sharps rifles are a series of large-bore, single-shot, falling-block, breech-loading rifles, beginning with a design by Christian Sharps in 1848 and ceasing production in 1881. They were renowned for long-range accuracy. By 1874, the rifle was available in a variety of calibers, and it was one of the few designs to be successfully adapted to metallic cartridge use. The Sharps rifles became icons of the American Old West with their appearances in many Western-genre films and books. Perhaps as a result, several rifle companies offer reproductions of the Sharps rifle.

In firearm designs, the term single-shot refers to guns that can hold only a single round of ammunition inside and thus must be reloaded manually after every shot. Compared to multi-shot repeating firearms ("repeaters"), single-shot designs have no moving parts other than the trigger, hammer/firing pin or frizzen, and therefore do not need a sizable receiver behind the barrel to accommodate a moving action, making them far less complex and more robust than revolvers or magazine/belt-fed firearms, but also with much slower rates of fire.