The siege of Cannanore was a four-month siege, from 27 April 1507 to 27 August 1507, when troops of the local ruler, supported by the Zamorin of Calicut and Arabs, besieged the Portuguese garrison at St. Angelo Fort in Cannanore, in what is now the Indian state of Kerala. It followed the Battle of Cannanore, in which the fleet of the Zamorin was defeated by the Portuguese.

St. Angelo Fort is a fort facing the Arabian Sea, situated 3 km from Canannore (Kannur), a city in Kerala state, south India.