The siege of Rhodes in 305–304 BC was one of the most notable sieges of antiquity, when Demetrius Poliorcetes, son of Antigonus I, besieged Rhodes in an attempt to make it abandon its neutrality and end its close relationship with Ptolemy I.

Demetrius I, called Poliorcetes, was a Macedonian Greek nobleman and military leader who became king of Macedon between 294–288 BC. A member of the Antigonid dynasty, he was the son of its founder, Antigonus I Monophthalmus and his wife Stratonice, as well as the first member of the family to rule Macedon in Hellenistic Greece.