Sikeston is a city located both in southern Scott County and northern New Madrid County, in the state of Missouri, United States. It is situated just north of the "Missouri Bootheel", although many locals consider Sikeston a part of it. By way of Interstate 55, Interstate 57, and U.S. Route 60, Sikeston is close to the halfway point between St. Louis and Memphis, Tennessee and is four hours from Nashville.

Scott County is located in the southeastern portion of the U.S. state of Missouri. As of the 2020 census, the population was 38,059. Its county seat is Benton. The county was organized in 1821 and named for U.S. Representative John Scott, the first federal representative from Missouri. Scott County comprises the Sikeston, MO Micropolitan Statistical Area, which is also included in the Cape Girardeau-Sikeston, MO-IL Combined Statistical Area. The county is home to Scott County Central High School, which has won 18 state championships in boys basketball—the most of any high school in the state.