The Sikorsky S-35 was an American triple-engined sesquiplane transport later modified to use three-engines. It was designed and built by the Sikorsky Manufacturing Company for an attempt by René Fonck on a non-stop Atlantic crossing for the Orteig Prize. It was destroyed in the attempt.

The Orteig Prize was a reward of $25,000 offered in 1919 by New York City hotel owner Raymond Orteig to the first Allied aviator, or aviators, to fly non-stop from New York City to Paris or vice versa. Several famous aviators made unsuccessful attempts at the New York–Paris flight before the relatively unknown American Charles Lindbergh won the prize in 1927 in his aircraft Spirit of St. Louis.