South African Airways Flight 201 (SA201), a de Havilland Comet 1, took off at 18:32 UTC on 8 April 1954 from Ciampino Airport in Rome, Italy, en route to Cairo, Egypt, on the second stage of its flight from London, England to Johannesburg, South Africa. The flight crashed at around 19:07 UTC, killing all on board. The flight was operated as a charter by British Overseas Airways Corporation (BOAC) using the aircraft G-ALYY, with a South African crew of seven, and carrying fourteen passengers.

The de Havilland DH.106 Comet is the world's first commercial jet airliner. Developed and manufactured by de Havilland in the United Kingdom, the Comet 1 prototype first flew in 1949. It features an aerodynamically clean design with four de Havilland Ghost turbojet engines buried in the wing roots, a pressurised cabin, and large windows. For the era, it offered a relatively quiet, comfortable passenger cabin and was commercially promising at its debut in 1952.