The South Carolina Governor's School for Science and Mathematics is a public, boarding high school for students in grades 11 and 12, located in Hartsville, South Carolina. The school concentrates on science and mathematics, but offers the full spectrum of the humanities as well.

Hartsville is the largest city in Darlington County, South Carolina, United States. It was chartered on December 11, 1891. The population was 7,764 at the 2010 census. Hartsville was chosen as an All-America City in 1996 and again in 2016. Hartsville has also been a National Arbor Day Foundation Tree City since 1986.