South Waziristan District was a district in the Dera Ismail Khan Division of the Khyber Pakhtunkhwa province of Pakistan, before splitting into the Lower South Waziristan District and the Upper South Waziristan District on 13 April 2022. It covers around 11,585 km2 (4,473 mi2). Waziristan is located in the southwest of Khyber Pakhtunkhwa. It is situated between two rivers, the Tochi River to the north and the Gomal River to the south. The region was an independent tribal territory from 1893, separated from both Afghanistan and the British-ruled empire in the subcontinent. Raiding the tribal areas was a constant problem for the British, requiring frequent punitive expeditions between 1860 and 1945. Troops of the British Raj coined a name for this region "Hell's Door Knocker" in recognition of the fearsome reputation of the local fighters and inhospitable terrain. The district headquarter of the South Waziristan district is Wanna. South Waziristan is divided into three administrative subdivisions of Ladha, Sarwakai, and Wanna. These three subdivisions are further divided into eight Tehsils: Ladha, Makin, Sararogha, Sarwakai, Tiarza, Wanna, Barmal, and Toi Khula.

The Gomal is a 400-kilometre-long (250 mi) river in Afghanistan and Pakistan. It rises in northern Afghanistan's Paktika Province and joins the Indus River 20 miles south of Dera Ismail Khan, in Pakistan's Khyber Pakhtunkhwa province.