Southaven is a city in DeSoto County, Mississippi, United States. It is a principal city in Greater Memphis. The 2020 census reported a population of 54,648, making it the 3rd most populous city in Mississippi and the 2nd most populous suburb of Memphis. Southaven is traversed north to south by the I-55/I-69 freeway. The city's name derives from the fact that Southaven is located south of Whitehaven, a neighborhood in Memphis.

DeSoto County is a county located on the northwestern border of the U.S. state of Mississippi. As of the 2020 census, the population was 185,314, making it the third-most populous county in Mississippi. Its county seat is Hernando.