Southern Comfort is an American, naturally fruit-flavored, whiskey liqueur with fruit and spice accents. The brand was created by bartender Martin Wilkes Heron in New Orleans in 1874, using whiskey as the base spirit. Whiskey was replaced by a neutral spirit under the ownership of Brown–Forman. On March 1, 2016, the Sazerac Company purchased it, and reintroduced whiskey as its base spirit.

A liqueur is an alcoholic drink composed of spirits and additional flavorings such as sugar, fruits, herbs, and spices. Often served with or after dessert, they are typically heavily sweetened and un-aged beyond a resting period during production, when necessary, for their flavors to mingle.