The Southwest Region or South-West Region is a region in Cameroon. Its capital is Buea. As of 2015, its population was 1,553,320. Along with the Northwest Region, it is one of the two Anglophone (English-speaking) regions of Cameroon. Various Ambazonian nationalist and separatist factions regard the Sud-Ouest region as being distinct as a polity from Cameroon.

Cameroon, officially the Republic of Cameroon, is a country in Central Africa. It shares boundaries with Nigeria to the west and north, Chad to the northeast, the Central African Republic to the east, and Equatorial Guinea, Gabon and the Republic of the Congo to the south. Its coastline lies on the Bight of Biafra, part of the Gulf of Guinea and the Atlantic Ocean. Due to its strategic position at the crossroads between West Africa and Central Africa, it has been categorized as being in both camps. Its nearly 27 million people speak 250 native languages, in addition to the national tongues of English and French, or both.