Soyuz MS-22 was a Russian Soyuz spaceflight to the International Space Station with a crew of three launched from Baikonur Cosmodrome on 21 September 2022. The launch, previously planned for 13 September 2022, was subsequently delayed to 21 September 2022 for a mission length of 188 days.

Francisco Carlos "Frank" Rubio is an American flight surgeon, US Army colonel and helicopter pilot, and NASA astronaut. He holds the American record for the longest spaceflight at 371 days.