SpaceX CRS-6, also known as SpX-6, was a Commercial Resupply Service mission to the International Space Station, contracted to NASA. It was the eighth flight for SpaceX's uncrewed Dragon cargo spacecraft and the sixth SpaceX operational mission contracted to NASA under a Commercial Resupply Services contract. It was docked to the International Space Station from 17 April to 21 May 2015.

Commercial Resupply Services (CRS) are a series of flights awarded by NASA for the delivery of cargo and supplies to the International Space Station (ISS) on commercially operated spacecraft. The first CRS contracts were signed in 2008 and awarded $1.6 billion to SpaceX for twelve cargo Dragon and $1.9 billion to Orbital Sciences for eight Cygnus flights, covering deliveries to 2016. The Falcon 9 and Antares rockets were also developed under the CRS program to deliver cargo spacecraft to the ISS.