Space Ghost Coast to Coast is an American adult animation created by Mike Lazzo for Cartoon Network and first broadcast in 1994. It takes the form of a surreal parody of talk shows, hosted by a reimagined version of the 1960s Hanna-Barbera cartoon character Space Ghost. It incorporates surrealism and non-sequitur humor.

A talk show is a television programming, radio programming or Podcast genre structured around the act of spontaneous conversation. A talk show is distinguished from other television programs by certain common attributes. In a talk show, one person discusses various topics put forth by a talk show host. This discussion can be in the form of an interview or a simple conversation about important social, political or religious issues and events. The personality of the host shapes the tone and style of the show. A common feature or unwritten rule of talk shows is to be based on "fresh talk", which is talk that is spontaneous or has the appearance of spontaneity.