The Spokane River is a tributary of the Columbia River, approximately 111 miles (179 km) long, in northern Idaho and eastern Washington in the United States. It drains a low mountainous area east of the Columbia, passing through the Spokane Valley and the city of Spokane, Washington.

The Columbia River is the largest river in the Pacific Northwest region of North America. The river forms in the Rocky Mountains of British Columbia, Canada. It flows northwest and then south into the U.S. state of Washington, then turns west to form most of the border between Washington and the state of Oregon before emptying into the Pacific Ocean. The river is 1,243 miles long, and its largest tributary is the Snake River. Its drainage basin is roughly the size of France and extends into seven states of the United States and one Canadian province. The fourth-largest river in the United States by volume, the Columbia has the greatest flow of any river entering the Pacific outside of Asia, and the 36th greatest discharge of any river in the world.